Do you or someone close to you have metastatic colorectal cancer

Read more about the AGENT Study

Do you or someone close to you have metastatic colorectal cancer

Read more about the AGENT Study

The AGENT Study is conducted at nearly 80 research centers throughout the U.S., Canada and western Europe. This global study is a Phase 3 clinical trial evaluating arfolitixorin as a first-line treatment of metastatic colorectal cancer (mCRC).

Colorectal cancer (CRC) is one of the most common forms of cancer with more than 1.8 million new cases identified globally every year. There have been no significant advances in the treatment of CRC for decades. Arfolitixorin is a new experimental therapy being developed to improve the effectiveness of standard of care chemotherapy for patients living with mCRC.

arfolitixorin animation
The animation that explains how arfolitixorin works in cancer cells, describing the mechanism of action.

Listen to recent episode from The Cancer Gene podcast features Anders Rabbe, CEO of Isofol, discussing colorectal cancer and the company’s ongoing Phase 3 study

Glossary


Control - an experiment or observation intended to help minimize the effects of all variables in a study that are not the target of the study itself


Clinical study - an organized research program used to evaluate the safety and effectiveness of a new medical treatment or device


Clinical study coordinator - a person with administrative responsibilities at an individual clinical study site that helps with enrollment and maintaining contact with patients and study organizers


Contract research organization - a third party company often hired to handle the logistics of running a large-scale clinical study that involves multiple clinical study sites


Duration of response (DOR) - time between the initial response to therapy and subsequent disease progression or relapse


Eligibility criteria - pre-defined standards used to determine if a person is able to take part in a clinical study


Endpoints - biomedical or behavioral measures of whether or not a treatment or device is effective determined during study design


First-line treatment - the first treatment a patient receives for a certain stage of disease


Food and Drug Administration (FDA) - a federal agency of the U.S. charged with ensuring the safety of food and drugs. The main federal oversight organization for all clinical studies


Health-related biomedical or behavioral outcomes - conditions that can be used to reflect or measure the overall health of an individual (for example: heart rate, lung capacity, disease progression measures such as tumor size, etc.)


Intervention - a treatment or process that is a focus of a clinical study. For example, giving a study subject a new experimental drug is an intervention, as is giving someone a placebo


MTHF - Methylenetetrahydrofolate


Overall response rate (ORR) - portion of patients with a tumor size reduction of a predefined amount


Phase - the name for a stage of clinical testing


Placebo - an inactive substance or other innocuous intervention that looks the same as and is given the same way as the experimental drug or intervention that is the focus of a study


Principal investigator - the person who is responsible for the scientific and technical direction of the entire clinical study, either at a single clinical study site or over the whole study


Progression free survival (PFS) - time during and after treatment of a disease that a patient lives with the disease without it getting worse


Toxicology - a branch of science concerned with measuring the nature and effects of poisons or other harmful agents